The blocking mAB to EPCR induces changes in fibrinogen consumption, fibrin degradation products, blood pressure, soluble TM, IL-6, and IL-8 levels.

(A) Fibrinogen levels were determined as a function of time after infusion of sublethal E coli and (1) the blocking mAb (■) (2) the control mAb (□), and (3) saline (▴). The same symbols are used to identify the experimental groups throughout this figure; (B) Fibrin degradation products; (C) Blood pressure (MSAP); (D) Soluble TM; (E) IL-6; and (F) IL-8. All assays were performed at least in triplicate and the error bar represents the standard error of the mean from all animals in the group. When error bars are not shown in this and other figures, the error was smaller than the data point on the graph.