Photographs of sections of the liver from baboons injected with sublethal doses of E coli and blocking anti-EPCR mAbs.

In the “early” animals (ie, animals with relatively short survival) the portal areas of the liver (A) are quite unremarkable with well-preserved architecture showing the bile duct (B), portal vein (P), hepatic artery, and numerous hepatocytes. The centrilobular regions (C) of the liver from the “early” animals exhibit prominent PMN infiltrate in association with necrobiotic/necrotic changes of scattered hepatocytes. The “late” changes (ie, changes in animals with relatively long survival) consist of “open” nuclei (ie, nuclei with pale chromatin pattern) and prominent nucleoli in the hepatocytes both in the portal (B) and centrilobular (D) regions and vacuolar degeneration of the hepatocytes more severe in the centrilobular area (D). Note (B) the well-preserved portal structures with bile duct (B), hepatic artery, and portal vein (P). Note also the lack of PMN infiltrate in the centrilobular area (D).