Antigen-induced eosinophil infiltration into the airways is diminished in both Stat5a^−/− mice and Stat5b^−/− mice.

(A) OVA-sensitized Stat5a^−/− mice, Stat5b^−/− mice, and littermate wild-type mice were challenged with the inhalation of OVA or saline (as control), and the number of eosinophils infiltrating into the submucosal tissue of trachea was evaluated at 24 hours after the inhalation. Data are means ± SD for 8 mice in each group. The mean values in Stat5a^−/− mice and Stat5b^−/− mice are significantly different from the mean value of wild-type mice, *P < .001. (B) Similar to A, the number of eosinophils in BALF was evaluated at 36 hours after the inhalation. Data are means ± SD for 5 mice in each group. *P < .005.