Diminished antigen-induced proliferation of splenocytes in Stat5a^−/− mice and Stat5b^−/− mice.

(A) Splenocytes from OVA-sensitized mice were cultured in the presence or absence of 200 μg/mL of OVA for 72 hours. Data are means ± SD for 5 mice in each group. *Significantly different from the mean value of wild-type mice, *P < .005. (B) Splenocytes from OVA-sensitized mice were stimulated with or without plate-coated anti-CD3 mAb for 72 hours. Data are means ± SD for 5 mice in each group.