Pathological analysis ofBCR/ABLtg/−p53+/− leukemic mice.
Figures 2A to 2D show Wright-Giemsa staining of stamped or smeared specimens of hematopoietic tissues. Massive proliferation of lymphoblasts is observed in the thymus (A) and in the pleural effusion (B). In mice with late onset of acute transformation, proliferation of granulocytes is evident in the peripheral blood (C) and the bone marrow shows marked hyperplasia of myeloid cells (D). Figures 2E to 2J show hematoxylin-eosin staining of tissue from the following: the lung (2E and 2F), liver (2G and 2H), and kidney (2I and 2J). Infiltration of leukemic cells was detected around the blood vessels. The boxed areas in Figures 2E, 2G, and 2I are magnified in Figures 2F, 2H, and 2J, respectively.
