Possible intron 4 splicing events as a result of the γ82 A→G substitution.

Conserved bases are underlined, and the invariant GT is in bold. The consensus 5′ splice site21 is shown above the line with the normal 5′ splice site for intron 4 shown below. γ82 A→G introduces a potential 5′ splice site by creating a new GT with 4 of the surrounding 7 bases adhering to the consensus sequence. Translation of this message would result in a truncated polypeptide ending in the novel sequence⁸²DICRKYIIQIIKRLLT.⁹⁷