Stabilization of the TCRBV repertoire in patients treated with antiretroviral therapy during primary HIV-1 infection.

The slope of the regression line of Δ over time was calculated as in Figure 1. HIV-1 viremia values were obtained by means of quantitative-competitive PCR, NASBA (Organon-Teknika), or branched DNA assay (Chiron, Emeryville CA), as described in footnotes to Table 1. (A) TCRBV repertoire stabilization in untreated subjects and patients treated with HAART during primary infection. The mean Δ slope in each subgroup is indicated by solid lines. (B) Correlation between TCRBV repertoire stabilization and the slope of HIV-1 viremia in untreated subjects during primary infection. Significance of the correlation was tested by means of linear regression analysis. (C) Correlation between TCRBV repertoire stabilization and the slope of HIV-1 viremia in subjects treated with antiretroviral therapy during primary infection. Significance of the correlation was tested by means of linear regression analysis.