Fig. 4.
![Fig. 4. Cytotoxic activity of HIV-specific and heterologous CTL clones derived from patient 0407 during primary HIV infection. / (A) CTL activity of T-cell micropopulations derived by limiting dilution was tested against autologous targets infected with a panel of recombinant vaccinia viruses expressing HIV-1 proteins. The significance threshold was set at 10% specific cytolytic activity. (B) DNA sequence of the CDR3 (V[D]J) region of the TCR β chain from the 4 CTL clones shown in A. The sequences used to design clonotype-specific probes are boxed. Nomenclature of TCRBV families is according to Arden et al.31](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/5/10.1182_blood.v95.5.1743.005k14_1743_1751/6/bloo00514004x.jpeg?Expires=1735533372&Signature=Pah~cPoIuFDCiRZd1fG6x0YaMXKD1N1f254Z90uGb34k01W2PnYj8y71Tgr2MPn3ssOmZXxX1DenDVcFHuR4gsjOq1xlueODprxFiNLXngDeT0HfLVmi~dYPS44g~vp3Z6kvz5oXKR6d3EZFMuuaVBu6Ljkh5yZ19Xa5cl8yNE8gnH8l6HVnTzTk5QMDDa~gO~c~4Ixi1lEOnSut9xH7hEmbDFQXp6oYbYiQ3iNdwtwLwas9y0VSgtkXOfz8cjdr8B2CERoukEfIUME1xcX1D-I5-CT4A1xZU8AfZ5cjqq7dVuVj2AFKpC3XpvIdnOcMXWYU1PlkHMisNMLuz02P0g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cytotoxic activity of HIV-specific and heterologous CTL clones derived from patient 0407 during primary HIV infection.
(A) CTL activity of T-cell micropopulations derived by limiting dilution was tested against autologous targets infected with a panel of recombinant vaccinia viruses expressing HIV-1 proteins. The significance threshold was set at 10% specific cytolytic activity. (B) DNA sequence of the CDR3 (V[D]J) region of the TCR β chain from the 4 CTL clones shown in A. The sequences used to design clonotype-specific probes are boxed. Nomenclature of TCRBV families is according to Arden et al.31
