Schematic representation of FGFR1, CEP110, and both CEP110-FGFR1 and FGFR1-CEP110 chimeric proteins.

FGFR1 domains are indicated as follows: IgI, IgII, IgIII, the 3 immunoglobulin-like domains; TM, the transmembrane domain; TK1 and TK2, the tyrosine kinase 1 and 2 subdomains interrupted by a kinase insert (KI). CEP110 regions are indicated as follows: diamonds, leucine zipper motifs; waved lines, predicted coiled-coil region. Double arrows indicate the t(8;9) breakpoint. Nucleotide and amino acids sequences are indicated for CEP110-FGFR1 and both wild-type products.