Schematic representation of the BCL-6 5′ noncoding region mutations in molecular clones derived from NHL samples, demonstrating intraclonal diversification and biallelic mutations.

Molecular clones are derived from NHL samples 1 (A) and 3 (B). Each sequence is represented as a horizontal line. The first nucleotide of the amplified BCL-6 gene region, corresponding to the first nucleotide of the sense primer is arbitrarily defined as position +1. In each sequence, mutations are indicated as circles. The nature of each mutation is specified in Table 1. Arrows indicate identical biallelic mutations. Star indicates 397 C polymorphism.