Fig. 1.
Plasma levels of prothrombin fragment, TpP, and D-dimer.
Plasma levels (mean ± SEM) of prothrombin fragment (F1 + 2, top panel), thrombus precursor protein (TpP, middle panel), and D-dimer (bottom panel) are shown before and after LPS infusion (2 ng/kg) in human volunteers receiving either placebo (○) or recombinant lepirudin (▪), (n = 12 per group). *P < .05 versus baseline, # < .05 for comparisons between the groups.