Plasma levels of TFPI, AT III, and TAT.

Plasma levels (mean ± SEM) of tissue factor pathway inhibitor (TFPI, top panel), antithrombin III (AT III, middle panel), and thrombin-antithrombin III complexes (TAT, bottom panel) are shown before and after LPS infusion (2 ng/kg) in human volunteers receiving either placebo (○) or lepirudin (▪), (n = 12 in both groups). *P < .05 versus baseline, #P < .05 for comparisons between the groups.