Plasma levels of PAP, t-PA, and PAI-1.

Plasma levels (mean ± SEM) of plasmin-α₂-antiplasmin complexes (PAP, top panel), tissue plasminogen activator (t-PA, middle panel), and plasminogen activator inhibitor (PAI-1, bottom panel) are shown before and after LPS infusion (2 ng/kg) in human volunteers receiving either placebo (○) or lepirudin (▪), (n = 12 in both groups). *P < .05 versus baseline.