Desensitization of neutrophil superoxide production.
In the upper part of the figure (A and B) the cells were first activated with fMLF (10−7 mol/L) and this was then followed (10 minutes later) by a restimulation with the same concentration of either fMLF (A; homologous desensitization) or WKYMVm (B; no desensitization). In the lower part of the figure (C and D) the cells were first activated with WKYMVm (10−7 mol/L) and this was then followed (10 minutes later) by a restimulation with the same concentration of either WKYMVm (C; homologous desensitization) or fMLF (D; heterologous desensitization). The arrows indicate the times for addition of an agonist and the curves are from a representative experiment. Abscissa, time of study (minute); ordinate, cellular production of superoxide anion expressed in CL units (Mcpm = 106 cpm).
