Levels of antigenic granzyme A (GrA) and GrA-antithrombin III (ATIII) complexes are correlated.

(A) Levels of antigenic GrA and GrA-ATIII complexes in plasma samples of healthy individuals or subjects with Dengue fever. The lines represent the median level for each group. (B) Correlation between GrA antigen and GrA-ATIII levels in plasma of patients (n = 30) with Dengue fever (Spearman r = 0.4025; P = .017). (C) Course of GrA antigen and GrA-ATIII complex levels in a renal transplant recipient that developed a cytomegalovirus (CMV) infection after surgery. The day of surgery was appointed day 0, the arrow represents the time of diagnosis of CMV infection. GrA and GrA-ATIII complexes were detected by enzyme-linked immunosorbent assays described in “Materials and Methods.” Note the difference in the scale for antigenic GrA (left Y-axis) and GrA-ATIII complexes (right Y-axis).