Fig. 7. FISH analysis of LAMA84 and LAMA84R cell lines. / (A) Interphase nuclei from LAMA84 displaying 2, 3, and 5 copies of the fused BCR/ABL signal indicating the BCR/ABL chimeric gene. (B) Metaphase spreads in the same cell line showing the modal number of 4 copies of BCR/ABL per cell. In contrast to the single fused signals observed in LAMA84, the resistant LAMA84R line additionally displayed an amplified signal containing multiple copies of BCR/ABL. (C) Interphase nuclei from LAMA84R showing the amplified signal plus single copies of the fused signal. (D) A metaphase sample of LAMA84R shows a similar signal compatible with the amplified element, shown at higher magnification in (E).
Fig. 7.

FISH analysis of LAMA84 and LAMA84R cell lines.

(A) Interphase nuclei from LAMA84 displaying 2, 3, and 5 copies of the fused BCR/ABL signal indicating the BCR/ABL chimeric gene. (B) Metaphase spreads in the same cell line showing the modal number of 4 copies of BCR/ABL per cell. In contrast to the single fused signals observed in LAMA84, the resistant LAMA84R line additionally displayed an amplified signal containing multiple copies of BCR/ABL. (C) Interphase nuclei from LAMA84R showing the amplified signal plus single copies of the fused signal. (D) A metaphase sample of LAMA84R shows a similar signal compatible with the amplified element, shown at higher magnification in (E).

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