Fig. 2.
Fig. 2. The peripheral accumulation of TNF-–producing T cells is linked to their escape from apoptosis. / Apoptosis susceptibility of TNF-α+ T cells was determined by concomitant intracellular TNF-α+and 7-AAD stainings. (A) Dot-plots of gated CD3+ T cells from a representative HIV+ patient before HAART and at M12. (B) Follow-up of susceptibility to activation-induced apoptosis of TNF-α+T cells during HAART. Vertical bars indicate SEM. (C) Scatter-plots of apoptosis rates in TNF-α+ T cells and percentages of TNF-α+ peripheral cells in 16 patients who received at least 9 months of HAART (Spearman rank correlations). Values are given as the mean plus or minus SD. Shaded box indicates HIV+PI− patients; open circle, CD4 T cells; and closed circle, CD8 T cells. Asterisk indicates P < .05 vs baseline values (Wilcoxon signed rank test); paragraph symbol,P < .05 vs HIV− controls (Mann-Whitney U test).

The peripheral accumulation of TNF-–producing T cells is linked to their escape from apoptosis.

Apoptosis susceptibility of TNF-α+ T cells was determined by concomitant intracellular TNF-α+and 7-AAD stainings. (A) Dot-plots of gated CD3+ T cells from a representative HIV+ patient before HAART and at M12. (B) Follow-up of susceptibility to activation-induced apoptosis of TNF-α+T cells during HAART. Vertical bars indicate SEM. (C) Scatter-plots of apoptosis rates in TNF-α+ T cells and percentages of TNF-α+ peripheral cells in 16 patients who received at least 9 months of HAART (Spearman rank correlations). Values are given as the mean plus or minus SD. Shaded box indicates HIV+PI− patients; open circle, CD4 T cells; and closed circle, CD8 T cells. Asterisk indicates P < .05 vs baseline values (Wilcoxon signed rank test); paragraph symbol,P < .05 vs HIV− controls (Mann-Whitney U test).

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