Fig. 5.
Fig. 5. Expression of human Aγ-globin mRNA in transgenic mice containing the BGT54 construct. / S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT54 is expressed at significant levels in 13 of the 15 transgenic mice. These data show that the β-globin promoter element and 3′ enhancer sequence are not sufficient for reproducible single-copy transgene expression. Abbreviations as described in Figure 3.

Expression of human Aγ-globin mRNA in transgenic mice containing the BGT54 construct.

S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT54 is expressed at significant levels in 13 of the 15 transgenic mice. These data show that the β-globin promoter element and 3′ enhancer sequence are not sufficient for reproducible single-copy transgene expression. Abbreviations as described in Figure 3.

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