Fig. 6.
Fig. 6. Expression of human Aγ-globin mRNA in transgenic mice containing the BGT50 construct. / S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT50 is expressed in all 8 animals, including 7 single-copy mice. These data show that the β-globin intron 2 and 3′ enhancer elements are sufficient for reproducible transgene expression when linked to the 5′HS3 element and the β-globin promoter. Abbreviations as described in Figure 3.

Expression of human Aγ-globin mRNA in transgenic mice containing the BGT50 construct.

S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT50 is expressed in all 8 animals, including 7 single-copy mice. These data show that the β-globin intron 2 and 3′ enhancer elements are sufficient for reproducible transgene expression when linked to the 5′HS3 element and the β-globin promoter. Abbreviations as described in Figure 3.

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