Fig. 7.
Fig. 7. Expression of human Aγ-globin mRNA in transgenic mice containing the BGT76 construct. / S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT76 is expressed in all 17 animals, including 5 single-copy mice. These data show that activation of single-copy transgenes by a functional interaction between 5′HS3, the β-globin intron 2, and 3′ enhancer elements is not specific for the β-globin promoter. Abbreviations as described in Figure3.

Expression of human Aγ-globin mRNA in transgenic mice containing the BGT76 construct.

S1 nuclease analysis on fetal liver RNA of 15.5-day founder transgenic mice showing that BGT76 is expressed in all 17 animals, including 5 single-copy mice. These data show that activation of single-copy transgenes by a functional interaction between 5′HS3, the β-globin intron 2, and 3′ enhancer elements is not specific for the β-globin promoter. Abbreviations as described in Figure3.

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