Pedigrees of the ALD families.

Black symbols mark subjects with cancer. Arabic numbers indicate the type of cancer: 1, gastric carcinoma; 2, lymphoma; 2B, Hodgkin lymphoma; 3, small cell lung cancer; 4, polycythemia vera; 5, colon carcinoma; 6, breast carcinoma; 7, lung carcinoma; 8, kidney adenocarcinoma; 9, squamous head carcinoma. Gray symbols mark subjects with autoimmune disease. In each family the ALD patient is the single affected individual in the third generation. Lower-case letters indicate the type of autoimmune disease: a, IDDM; b, chronic hemolytic anemia, c, autoimmune thrombocytopenia; d, neutropenia; e, SLE; f, multiple sclerosis; g, RA; h, autoimmune hepatitis; i, ankylosing spondylitis; j, polyarthritis.