Fig. 3.
![Fig. 3. Effects of peptide inhibitors of caspases on Fas- or tumor-induced DNA degradation in Jurkat cells. / [3H]TdR-labeled Jurkat cells were pretreated with Z-VAD-FMK or Z-DEVD-FMK at the indicated concentrations for 16 hours and then coincubated with tumor at a 40:1 tumor-to-lymphocyte cell ratio for an additional 16 hours. Jurkat cell apoptosis was determined by measuring the loss of 3H-labeled DNA. The error bars represent the SEM of 8 replicates. Similar results were obtained in the absence of inhibitors or in the presence of the control inhibitor Z-FA-FMK.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/6/10.1182_blood.v95.6.2015/6/bloo00630003x.jpeg?Expires=1735573125&Signature=EYkmSZzxcbKuWWAKp1MdJP0wFQiHPwwmS7TuW9fDWH3ZC6tc1W8y8M4iM8b~lf~9jNLV9O3zY3r6ueON4tmG1Iq6wGnU3wyYsIFvQKMHY3Ac~SP4QJ9Ge2uF77nPKpdp6ZaVsnT8DG3Fo9vnWwTlNPoAJVGJGx~V-E~kWBexituV-Ia8WhKeaVqAIlurrPQKjFLyYrrD-N5IJOSiPyEinEkN7~ipgZpVeiJFvD0MVVUF5f6~Nj6LCtxrmSxsta3HSY2-Fy-tbvnC77ata4sVFd8uzToCqOPxQI~DtPihyL0ZhsVZJMzOoIxtnrmB9f5GDnHwpuGgznbHZQubTwp1BA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effects of peptide inhibitors of caspases on Fas- or tumor-induced DNA degradation in Jurkat cells.
[3H]TdR-labeled Jurkat cells were pretreated with Z-VAD-FMK or Z-DEVD-FMK at the indicated concentrations for 16 hours and then coincubated with tumor at a 40:1 tumor-to-lymphocyte cell ratio for an additional 16 hours. Jurkat cell apoptosis was determined by measuring the loss of 3H-labeled DNA. The error bars represent the SEM of 8 replicates. Similar results were obtained in the absence of inhibitors or in the presence of the control inhibitor Z-FA-FMK.
