c-myc missense mutations in lymphomas.

Upper panel, summary of reported missense mutations in the c-myc coding region in Burkitt's lymphomas, AIDS-related lymphomas, B-cell acute lymphoblastic leukemias and the 3 avian v-myc-containing acute transforming retroviruses MC29, OK10, and MH2, representing 32 primary tumors and 28 cell lines.4-13 Amino acid positions of the most frequently mutated residues are indicated. Below is shown the c-Myc structure with indicated conserved regions. MB1; Myc box 1, MB2; Myc box 2, TAD; transactivation domain, Acidic; central acidic region, NLS; nuclear localization signal, BR; basic region, HLH; helix-loop-helix motif, Zip, leucine zipper motif, P; clusters of in vivo phosphorylation sites.1 The box at upper right shows the amino acid sequence of the conserved Myc box 1, including the Thr58 and Ser62 phosphorylation sites. GSK3; glycogen synthase kinase 3, MAPK; mitogen activated protein kinase, CDK; cyclin-dependent kinase. Asterisk (*) denotes the positions of frequent missense mutations. Lower panel, amino acid positions of c- or v-myc missense mutations in cell lines or constructs used in the study.