The effect of macrophage depletion on the liver uptake and blood decay of oxidatively damaged red blood cells (OxRBC).

Liposomes containing dichloromethylene diphosphonate (L-DMDP) were injected 45 hours prior to the injection of OxRBC. (A) Liver uptake (circles) and blood decay (triangles) of OxRBC after pretreatment with L-DMDP (closed symbols) or after injection of phosphate-buffered saline (PBS) (open symbols) as control. (B) Tissue distribution of OxRBC after injection of L-DMDP (black bars) or PBS (hatched bars). Tissues were taken at 30 minutes after injection of OxRBC and shown are the mean of 2 ± SEM. *P < .05; **P < .005.