The effect of polyanions, fucoidan, or oxidized low-density lipoprotein (OxLDL) on the liver and spleen uptake of oxidatively damaged red blood cells (OxRBC).

Liver (black bars) and spleen (hatched bars) uptake after injection of OxRBC. At 2 minutes before the injection of OxRBC, the indicated inhibitors were injected at the following amounts: polyadenosinic acid and polyinosinic acid: 200 μg (n = 3 ± SEM); fucoidan: 15 mg (n = 2 ± SEM); OxLDL: 150 μg protein (n = 2 ± SEM). *P < .05; **P < .001.