Structure of D4βc.
(A) Structure of the Fab receptor D4βc complex shown in ribbon representation. The mAb light chain is shown in cyan blue, the heavy chain in blue, and the receptor in yellow. The major structural features of D4βc are labeled, and the locations of key residues are denoted by stick representation. These pictures were produced using the Molscript20 and Raster3D21programs. (B) Structure as for (A) but reoriented 90° about the vertical axis. (C) Surface representation of the receptor using the program GRASP.22 The green surface indicates the location of hydrophobic-aromatic patch H1. The molecule is tilted approximately 20° counterclockwise relative to (A). (D) View of hydrophobic-aromatic patch H2 prepared as for (C). The molecule is tilted approximately 20° clockwise and rotated approximately 60° clockwise from above, about a vertical axis relative to (B).
