Restriction maps and sequences of the breakpoint regions on normal and derivative chromosomes.

The respective regions of germline chromosomes 1 and 14 are shown, with sites of breakpoint indicated by arrows. The location of PP1 is indicated. Sequences shown are chromosome 14, a germline IGHG4heavy chain switch region (GenBank accession number 56,796); chromosome 1; PAC 35A12; der(14); phage clone g401; and der(1), a PCR product amplified as detailed in “Materials and methods.”