Rearrangement and increased copy number of MUC1in B-cell NHL.

Tumor DNA was digested with the respective enzymes and hybridized with the PP1 probe. Rearranged bands in the tumor DNA compared to normal placenta (N) are indicated by arrows (A). Size markers are given in kbp. The calculated copy numbers of MUC1 are listed relative to normal placenta (N) using the hybridization signal from the probe D2S48 to control for loading (B).14 The numbers of tumors in each study group with 1 to 3 (normal) and 4 to 6 (increased) copy numbers ofMUC1 are shown (C).