Involvement of 12-LOX in endothelial cell tubelike differentiation.

The formation of cordlike structures by RV-ECT cells was facilitated by Matrigel as detailed in “Materials and methods.” (A) RV-ECT treated with ethanol as control. Original magnification, ×40. (B) RV-ECT treated with 10 μmol/L BHPP. Original magnification, ×40. (C) RV-ECT treated with ethanol as control. Original magnification, ×100. (D) RV-ECT treated with 10 μmol/L BHPP. Original magnification, ×100. Shown here are typical observations from 4 independent studies on the tube-forming ability of RV-ECT and the effect of BHPP.