Fig. 1.
Fig. 1. 5′ RACE assay of patients 1 and 2 and RT-PCR analysis of 5′ noncoding region of Ikaros gene. / (A, B) The foreign sequences identified with the 5′-RACE method in 2 patients with DLBL with t(3;7)(q27;p12). (A) patient 1, (B) patient 2. The foreign sequences fused to BCL6sequence are underlined. GenBank accession no. AF180297. (C) Sequence of the same RT-PCR products of 4 B-cell lines obtained with a sense primer (shown by arrow) for the foreign sequence identified in patient 2 and an antisense primer (shown by dashed arrow) for the Ikaros coding region. The foreign sequence (underlined) in this patient was found to correspond to a part of the 5′ noncoding region of theIkaros gene. The translation initiation ATG codon of theIkaros gene is indicated with 3 asterisks.

5′ RACE assay of patients 1 and 2 and RT-PCR analysis of 5′ noncoding region of Ikaros gene.

(A, B) The foreign sequences identified with the 5′-RACE method in 2 patients with DLBL with t(3;7)(q27;p12). (A) patient 1, (B) patient 2. The foreign sequences fused to BCL6sequence are underlined. GenBank accession no. AF180297. (C) Sequence of the same RT-PCR products of 4 B-cell lines obtained with a sense primer (shown by arrow) for the foreign sequence identified in patient 2 and an antisense primer (shown by dashed arrow) for the Ikaros coding region. The foreign sequence (underlined) in this patient was found to correspond to a part of the 5′ noncoding region of theIkaros gene. The translation initiation ATG codon of theIkaros gene is indicated with 3 asterisks.

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