Effects of induction chemotherapy on microvessel density in the bone marrow of patients with acute myeloid leukemia (AML).

Microvessel counts are depicted for day 0 (presentation), day 16 of induction chemotherapy, the time of complete remission, and the control patients. Values are given as individual data points (mean values of microvessel counts for thrombomodulin [TM] and von Willebrand factor [vWF] staining). The difference of microvessel density for day 16 and complete remission was statistically significant compared with day 0 (P < .0001; Mann-Whitney test). On day 16, patients with at least 5% residual blast infiltration (closed circles) had higher microvessel counts than patients without blast infiltration (open circles; P < .001, Mann-Whitney test).