Schematic representation of VH sequences of patients no. 3, 6, 8, and 66.

Each line represents the consensus sequence at a certain time point. Only mutations that differ between the sequences are shown. ○ represents an S mutation compared with the germline gene; • represents an R mutation. The codon numbers in which mutations took place are indicated under these symbols. The total number of somatic mutations for each FL sample (in bold) and the intraclonal variation, in number of mutations per clone, is indicated next to each line.