Inhibition of the DTH response by anti-IL-16 treatment.

Sensitized mice were treated with neutralizing mAb against IL-16 (14.1) or an isotype-matched control mAb (S-S.1) and challenged with mBSA into footpads. Footpad swelling was measured 0, 24, 48, and 72 hours after the Ag challenge. Data are shown as mean ± SD of 5 mice. *indicates P < .01 compared with control mAb. Similar results were obtained in 3 independent experiments.