Megabase map of the t(1;14)(q21;q32) and the location of the cosmid and P1 clones.

Clones S7D (Cγ+, Cα−) and S5F (Cγ+, Cα+) span the breakpoint on der(14). The restriction maps overlap, creating a mini-contig. Clones S5A and S7A (Cγ+) also comprise a mini-contig, and they span the breakpoint on the der(1) chromosome. The sizes of the translocated bands detected by PFGE are 140 kb for the derivative chromosome 14 and 600 kb for the derivative chromosome 1. PI-PAC clones 35(A12) and 35(A12) span a 100-kb region centered around the MUC1 gene.