Radiographs showing loss of heterozygosity (LOH) and microsatellite instability (MSI) in primary cutaneous T-cell lymphoma (CTCL).

Examples are shown of MSI and LOH on 10q detected by using microsatellite markers (D10S587, D10S209, D10S185, D10S215, and D10S541) in tumor samples from 6 patients with CTCL. The black arrow indicates allelic loss (LOH) in tumor (T) DNA with corresponding normal (N) alleles. The white arrow indicates novel alleles (MSI) in T DNA with corresponding N alleles.