Fig. 5.
Fig. 5. NPM-RAR decreases basal transcription of reporter constructs. Cells were transfected with pSG5, or expression plasmids encoding PML-RAR, NPMS-RAR or NPML-RAR along with a reporter construct and transfection control as in Figure1. Cells were harvested 16 hours after transfection, without addition of exogenous retinoic acid. The relative CAT enzyme activity for each experiment was normalized to the activity in cells transfected with pSG5. (A) TRE3-CAT in HeLa cells; (B) RARα2-CAT in K562 cells; (C) RARα2-CAT in HeLa cells.

NPM-RAR decreases basal transcription of reporter constructs. Cells were transfected with pSG5, or expression plasmids encoding PML-RAR, NPMS-RAR or NPML-RAR along with a reporter construct and transfection control as in Figure1. Cells were harvested 16 hours after transfection, without addition of exogenous retinoic acid. The relative CAT enzyme activity for each experiment was normalized to the activity in cells transfected with pSG5. (A) TRE3-CAT in HeLa cells; (B) RARα2-CAT in K562 cells; (C) RARα2-CAT in HeLa cells.

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