Effects of RAR- and RXR-selective retinoids on SCF-dependent mast cell growth.
(A) Dose response to RAR-selective retinoid (Ro 13-7410) or RXR-selective retinoid (Ro 25-7386) of mast cell growth supported by SCF. The 1 × 104 10-week cultured mast cells were incubated in wells containing SCF at 100 ng/mL with various concentrations of Ro 13-7410, Ro 25-7386, or ATRA. After 2 weeks, the viable cells were enumerated. Results shown are the mean ± SD of 3 experiments. Significantly different from SCF alone (*P < .0001). (B) No cooperative effects of Ro 13-7410 at concentrations of 10−10 mol/L to 10−7 mol/L and Ro 25-7386 at concentrations of 10−9 mol/L to 10−7 mol/L on the growth of mast cells supported by SCF. Significantly different from no Ro 25-7386 (*P < .0001).
