Fig. 4.
![Fig. 4. Nonstationary gamma model of platelet production and destruction mediated by Mpl-ligand. The endogenous thrombopoietin and exogenous PEG-rHuMGDF serum concentration time course, C(t), stimulates megakaryopoiesis; de novo platelet production rate, S[S0, C(t)], stimulated by Mpl-ligand begins after a megakaryocyte maturation delay time, τm. Newly formed platelets emerge into blood and are diluted in a volume, Vp, which includes blood volume and splenic pooling. Platelets progress through a sequence of na age compartments until they are lost from circulation by processes of random destruction, ρ, or reach the limit of intrinsic platelet longevity, Λ.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/8/10.1182_blood.v95.8.2514/4/bloo00825004x.jpeg?Expires=1735852015&Signature=KoqYTDACGG2bgHr3T4e97pLyYRrHM30KBoMHS2Ce5BtADdHdRfUbd-qLpQnqVFyMxW-ow8GeG2TGekTD8OZw24rI9GlgZ7Js8kdIcNBuwoem8glYHWB7XWx67BFvgAiNd~uL5sNjjjX8tTaHtSplh70dL8gz2G5dVSHFNVjk8wN2x7cmn~024ug4dvtQUDMzikNCXdFdphXtIwOyp1h3UWHhT8p2StFq2J4sRUfB90nGPp6Gca882w87~7UZ6a79YLZE-AF6ZoVhGOFTR3jGK33-JDWHOpVkYhT9Thqp4FTl3PCaVxY~5olJgrio3h~JaXl5QzI1FWlGIAyjnUz9yg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Nonstationary gamma model of platelet production and destruction mediated by Mpl-ligand. The endogenous thrombopoietin and exogenous PEG-rHuMGDF serum concentration time course, C(t), stimulates megakaryopoiesis; de novo platelet production rate, S[S0, C(t)], stimulated by Mpl-ligand begins after a megakaryocyte maturation delay time, τm. Newly formed platelets emerge into blood and are diluted in a volume, Vp, which includes blood volume and splenic pooling. Platelets progress through a sequence of na age compartments until they are lost from circulation by processes of random destruction, ρ, or reach the limit of intrinsic platelet longevity, Λ.
