Secretion of vascular endothelial growth factor (VEGF) by marrow mononuclear cells (MNCs) as well as tumor and nontumor cells.

VEGF concentrations were determined in supernatants of marrow MNCs from control subjects (n = 5), marrow MNCs from patients with multiple myeloma (MM; n = 5), and of the corresponding sorted tumor and nontumor cells of the MM marrows after 72 hours of culture. Data are presented as medians and interquartile ranges. The Mann-Whitney test was employed to identify differences between control MNCs and MM-MNCs (P < .0025) and between tumor and nontumor cells (P < .001).