Comparison of interleukin-6 (IL-6) secretion by bone marrow stromal cells (BMSCs) and multiple myeloma (MM)-BMSCs.

IL-6 levels in culture supernatants of BMSCs (A, C) and MM-BMSCs (B, D) were measured after stimulation with 0, 10, or 50 ng/mL of VEGF165 or VEGF121 for 48 hours, respectively. Data represent median values and interquartile ranges of stimulation experiments performed in triplicates using three different BMSC and MM-BMSC cultures.P < .05 for differences between basal IL-6 secretion of BMSCs and MM-BMSCs (Mann-Whitney test).