CD8⁺/CD4⁺ cell-dependent suppressive effect of CD8⁺ T cells from HIV-1 (PR-5 and PR-6, respectively) or HTLV-II (PR-1 and PR-3, respectively) monoinfected patients on HIV-1 p24 Ag production in cultures of CD4⁺ cells purified from a mono–HIV-1–infected individual.

From PR-1 and PR-5 (A), and from PR-6 and PR-3 (B), respectively. CD8⁺ cells were separated from HIV-infected CD4⁺ cells by a semipermeable membrane in a Transwell system. Cultures were performed in the absence or presence of anti-RANTES, anti-MIP-1α, and anti-MIP-1β polyclonal Abs (2 μg/mL each).