Exogenous hematopoietic growth factors block the differentiation-inducing effects of the p185, p210, and p230 Bcr-Abl proteins in primary bone marrow cells.

After retroviral-mediated gene transfer and expansion in the presence of cytokines and autologous stroma, GFP-positive cells were analyzed for the expression of surface markers associated with B cells (B220), and stem cells (CD34, Thy1.2, cKit, and CD 43) at the indicated times after infection.