The effect of antisense phosphorothioate DNA oligonucleotides to REDK is sequence-specific.

Low-density bone marrow cells were incubated with REDK sense (S223), antisense (AS480), mutant antisense (AS480M1, AS480M2), or DYRK2 antisense (AS DYRK2) and were plated in methylcellulose-based medium with synergistic factors, as described. BFU-E (upper panel) and CFU-E (lower panel) were scored at 12 and 7 days, respectively.