American Society of Hematology

Fig. 3.

$Fig. 3. Lack of cell cycle effects on short-term reconstitution by ex vivo expanded hematopoietic cells. / Lethally irradiated B6.SJL mice were injected with either 106 G0/G1 expanded cells (open squares; n = 23 mice from 4 experiments); 106S/G2/M expanded cells (closed squares; n = 10 mice from 4 experiments); or 2 × 106 unfractionated expanded cells that had been subjected to cell cycle arrest by in vitro exposure to AcSDKP (open circles; n = 13 mice from 2 experiments). Shown are the mean ± SEM number of (A) peripheral blood leukocytes, (B) erythrocytes, and (C) platelets counted on the indicated days after transplantation. Details of normal counts and thresholds for engraftment, as denoted by the shaded areas, are described in the Figure 1 legend.$

Lack of cell cycle effects on short-term reconstitution by ex vivo expanded hematopoietic cells.

Lethally irradiated B6.SJL mice were injected with either 10⁶ G₀/G₁ expanded cells (open squares; n = 23 mice from 4 experiments); 10⁶S/G₂/M expanded cells (closed squares; n = 10 mice from 4 experiments); or 2 × 10⁶ unfractionated expanded cells that had been subjected to cell cycle arrest by in vitro exposure to AcSDKP (open circles; n = 13 mice from 2 experiments). Shown are the mean ± SEM number of (A) peripheral blood leukocytes, (B) erythrocytes, and (C) platelets counted on the indicated days after transplantation. Details of normal counts and thresholds for engraftment, as denoted by the shaded areas, are described in the Figure 1 legend.

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