Fig. 5.
Fig. 5. In vivo treatment of transplant recipients with AcSDKP promotes the engraftment of ex vivo expanded hematopoietic cells. / Lethally irradiated mice were injected with the expanded progeny of Sca-1+c-kit+Lin− BM cells administered simultaneously with a single dose of 10 or 100 μg/mouse of AcSDKP. Recovery kinetics of (A) peripheral blood leukocytes, (B) erythrocytes, and (C) platelets were measured as described in Figure 1and are depicted by the closed circles (mean ± SEM values for 20 mice from 2 experiments). Hematopoietic reconstitution by freshly isolated Sca-1+c-kit+Lin− cells (hatched lines) or their expanded progeny transplanted without AcSDKP (open circles) is duplicated from Figure 1 for comparison (note scale change in panel A). Details of normal counts and thresholds for engraftment, as denoted by the shaded areas, are described in the Figure 1 legend.

In vivo treatment of transplant recipients with AcSDKP promotes the engraftment of ex vivo expanded hematopoietic cells.

Lethally irradiated mice were injected with the expanded progeny of Sca-1+c-kit+Lin− BM cells administered simultaneously with a single dose of 10 or 100 μg/mouse of AcSDKP. Recovery kinetics of (A) peripheral blood leukocytes, (B) erythrocytes, and (C) platelets were measured as described in Figure 1and are depicted by the closed circles (mean ± SEM values for 20 mice from 2 experiments). Hematopoietic reconstitution by freshly isolated Sca-1+c-kit+Lin− cells (hatched lines) or their expanded progeny transplanted without AcSDKP (open circles) is duplicated from Figure 1 for comparison (note scale change in panel A). Details of normal counts and thresholds for engraftment, as denoted by the shaded areas, are described in the Figure 1 legend.

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