Fig. 9.
Adenosine acting through A2A receptors may directly trigger the apoptosis of murine thymocytes and inhibit TCR-triggered activation by both A2A receptor-dependent and A2A receptor-independent mechanisms.
Receptor X is postulated to stimulate yet-to-be-determined TCR inhibiting pathway only in conditions of inhibited ADA. These effects of adenosine on TCR-triggered activation are not affected by inhibition of adenosine transport.
