Extended family pedigree.

Squares represent males; circles, females; diamonds, unspecified gender. The founder and partial pedigrees of 3 of his 12 children are depicted. Documented thrombocytopenia is indicated by solid figures; presumed or reported thrombocytopenia, striped figures; unaffected, open figures; unknown platelet status, question mark. Individuals who were studied during the genomic scan and those recruited to further delimit the area of linkage are indicated by an asterisk. Numbers inside diamonds indicate the number of offspring. Three unaffected children of unaffected individuals (not depicted) were included in the complete blood count and TPO data but were not used for genotyping. The generation and person numbers for each individual are used in Figures2-7.