Effects of APC, DEGR-FXa, heparin, DIP-APC, and leukocytopenia on renal histological feature in rats that had I/R.

Rats were subjected to 60 minutes of renal ischemia followed by reperfusion. Results are shown in rats in the sham-operation group (A and H), rats treated with I/R plus saline (B and I), rats treated with I/R plus APC (C and J); rats treated with I/R plus DEGR-FXa (D and K), rats treated with I/R plus heparin (E and L), rats treated with I/R plus DIP-APC (F and M), and rats treated with I/R and induction of leukocytopenia (G and N). For A, B, C, D, E, F, G, original magnification ×100; for H, I, J, K, L, M, and N, original magnification ×400.