Effects of APC, DEGR-FXa, heparin, DIP-APC, and leukocytopenia on the renal I/R-induced decrease in renal tissue blood flow in rats.

Rats were subjected to 60 minutes of renal ischemia followed by reperfusion. Renal tissue blood flow was measured from 30 minutes before ischemia until 3 hours after reperfusion. Data are expressed as mean ± SD values from 5 experiments. Closed circles indicate saline-treated rats; open circles, APC-treated rats; closed squares, DEGR-FXa–treated rats; open squares, heparin-treated rats; closed triangles, DIP-APC–treated rats; and open triangles, leukocytopenic rats. *P < .01 compared with saline-treated rats that had I/R.