MCP-1 induced angiogenesis in matrigel plugs.

The histologic appearance of matrigel plug sections after 7 days with or without MCP-1. (A) Matrigel plug section without MCP-1. (B) Matrigel plug containing 100 ng/mL of MCP-1. (C and D) The effects of Ab to MCP-1 (C) and control rabbit Ab (D) on matrigel plugs containing 100 ng/mL of MCP-1. As indicated, formation of vessels is basely observed in matrigel alone. “S” indicates stroma surrounding the plugs. Arrows point to endothelial cells forming vessels. All figures are at 340× magnification. One representative field from 2 experiments is shown.